"Preface The human body is subjected to numerous chemical exposures from the external environment. The atmosphere is the largest component of this environment, and, of the three portals for intoxication of the human body, the lungs are the largest surface exposed to this environment. Protecting the lungs from exposures to hazardous chemicals in the environment is often more difficult than protecting the human body from ingestion and dermal absorption hazards. Hazardous chemicals enter the body through the lungs in both the occupational and domestic environments. Among the substances frequently inhaled with air are an array of gases, aerosols, and particulates from natural and anthropogenic sources. In addition, some humans occasionally inhale therapeutic and/or abused drugs. The objective of Inhalation Toxicology is to provide the practicing professional as well as the aspiring student with a pragmatic textbook. It includes contributions from scientists in the academic, commercial/industrial, and governmental sectors and focuses on the regulatory aspects of exposure and testing, testing equipment and procedures, respiratory allergy and irritation of the respiratory tract, risk assessment, toxicology theory and toxicology modeling, and toxic effects of some individual toxicants. The contributors are from China, Germany, Israel, Slovenia, Switzerland, and United States"--Provided by publisher. Chapter 1. Collection and characterization of particulate matter deposition / Gregor Jereb, Sidney A. Katz, and Borut Poljésak -- chapter 2. Nose-only aerosol exposure systems : design, operation, and performance / Robert F. Phalen, Loyda B. Mendez, and Michael J. Oldham -- chapter 3. Lungs-on-a-chip / Shuichi Takayama, Joshua B. White, and Chao Zhang -- chapter 4. Human health risk assessment of inhaled materials / Rhian B. Cope, Patricia Nance, and Mike Dourson -- chapter 5. Application of inhalation toxicology concepts to risk and consequence assessments / Brian E. Hawkins, David J. Winkel, Patrick H. Wilson, and Ian C. Whittaker -- chapter 6. Time scaling of dose and time to response : the toxic load exponent / Juergen Pauluhn -- chapter 7. Improper use of Haber's Law results in erroneous fatality estimation from predictive models / Tom Ingersoll, Janet Moser, Douglas R. Sommerville, and Harry Salem -- chapter 8. Physiologically based kinetic modeling of inhalation / Harvey J. Clewell III, Jeffry D. Schroeter, and Melvin E. Andersen -- chapter 9. Nanomaterial inhalation exposure from nanotechnology-based consumer products / Yevgen Nazarenko, Paul J. Lioy, and Gediminas Mainelis -- chapter 10. Influence of physicochemical properties on the bioactivity of carbon nanotubes/nanofibers and metal oxide nanoparticles / Dale W. Porter and Vincent Castranova -- chapter 11. Inhalation toxicology of riot control agents / Harry Salem, Michael Feasel, and Bryan Ballantyne -- chapter 12. Incapacitating agents / Joseph L. Corriveau and Michael Feasel -- chapter 13. Exposure to ammonia / Finis Cavender and Glenn Milner -- chapter 14. Serpentine and amphibole asbestos / David M. Bernstein -- chapter 15. Pulmonary primary cells cocultured in a novel cell culture system, the integrated discrete multiple cell-type coculture system (IdMOC) : pulmonary cytotoxicity of eight cigarette smoke condensates and nicotine / Albert P. Li, Patricia Richter, Stephanie Cole, Janna Madren- Whalley, Jonathan Oyler, Russell Dorsey, and Harry Salem -- chapter 16. Animal models of chronic obstructive pulmonary disease (COPD) / Steven G. Kelsen -- chapter 17. Toxic inhalation injury : management and medical treatment / Arik Eisenkraft and Avshalom Falk. Chapter 18. Transcriptomic responses to crystalline silica exposure / Pius Joseph, Christina Umbright, and Rajendran Sellamuthu -- chapter 19. Mechanisms involved in the inhalation toxicity of phosgene / Wenli Li and Juergen Pauluhn -- chapter 20. Chemical warfare agents and nuclear weapons / Terry J. Henderson, Nabil M. Elsayed, and Harry Salem -- chapter 21. Emergency response planning guidelines / Finis Cavender -- ch. 22. Safety assessment of therapeutic agents administered by the respiratory routes / Shayne C. Gad.