A sample of cresol was submitted to the Comparative Toxicology Research Laboratory for evaluation of acute oral lethality, acute inhalation toxicity, eye irritation properties, skin irritation properties by the method of testing primary irritant substances in accordance with the procedure outlined La the Federal Register, Volume 38, Number 187, Part II, Section 1500.41, and for definition of industrial handling hazards involving acute exposures. A member of the Industrial Health Team (Toxicologist, Industrial Hygienist, and/or Industrial Physician) should be consulted for recommendation of additional safety evaluations or handling procedures which may be needed to support manufacture and/or use of this test material. The acute oral lethality of the test material is low. The acute oral LD50 value determined in 24 albino rats was found to be between 1.0 g/kg and 2.0 g/kg of body weight. The probability that internal injury might result from acute ingestion of amounts of the test material one might encounter incidental to industrial handling is minimal. The test material had an extremely severe effect upon the eyes of an albino rabbit. Direct contact with this material resulted in tissue destruction leading to permanent impairment of vision.