Record Display for the EPA National Library Catalog

RECORD NUMBER: 122 OF 172

Main Title Mutagenicity Evaluation of Tetrafluoroethylene in Cho/hprt Assay with Cover Letter dated 08/22/1986.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 86860000130
Stock Number OTS0510275
Additional Subjects Toxicology ; Health effects ; Tetrafluoroethylene (116-14-3) ; Genotoxicity ; Gene Mutations ; Mammals ; Hamsters ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 116-14-3
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0510275 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 24p
Abstract
The ability of tetrafluoroethylene to induce specific locus mutations at the HGPRT locus in cultured Chinese hamster ovary (CHO) cells (CHO/HGPRT Mutagenicity Assay) was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, tetrafluoroethylene, was tested at nominal concentrations of 0, 20, 40, 60, 80 and 100% for treatments with and without metabolic activation. Twenty two nonactivated cultures produced a range of 100.0 - 56.5% cell survival relative to the negative control and twenty two activated cultures produced a range of 133.4 - 49.3% relative cell survival. None of the cultures produced mutant frequencies significantly greater than the negative control with or without metabolic activation.