Record Display for the EPA National Library Catalog

RECORD NUMBER: 90 OF 326

OLS Field Name OLS Field Data
Main Title Initial Submission: Basic Toxicity of Methyl Mercaptoacetate with Cover Letter dated 08/26/1992.
CORP Author Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-10587
Stock Number OTS0570921
Additional Subjects Toxicology ; Health effects ; Methyl mercaptoacetate ; Toxicity ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Primary dermal irritation ; Guinea pigs ; Dermal ; Subchronic toxicity ; CAS No 2365-48-2 ; Toxic substances
Holdings
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Status
NTIS  OTS0570921 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 9p
Abstract
Groups of five male rats were administered 2-11 doses of the test compound by gavage at 10, 100 or 300 mg/kg over 2-15 days. Animals in the high-dose group either died or were euthanatized in poor condition after two doses. Abnormalities observed in the high-dose group included: dehydration; weakness; decreases in white blood cell count and glucose; increases in aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase, and urea nitrogen; and an increase in relative liver and kidney weights. A variety of gross and histopathologic changes were observed in the moribund animals of the high-dose group. Abnormalities in the mid-dose group were decreased feed intake and minor to moderate eosinophilic cytoplasmic changes in the liver. No treatment related effects were observed in the low-dose group. The test compound has been sold as a pure chemical in volumes of 0-7.5 kg/year; it is not currently sold.