Record Display for the EPA National Library Catalog
RECORD NUMBER: 86 OF 326
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Basic Toxicity of Acetoacet-O-Anisidide with Cover Letter dated 09/28/1992.|
|CORP Author||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Toxic substances ; Acetoacet-o-anisidide ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Primary dermal irritation ; Guinea pigs ; Dermal ; Subchronic toxicity ; Primary dermal sensitization ; Primary eye irritation ; Rabbits ; Diet ; CAS No 92-15-9|
Groups of five rats were fed 0.1 or 1.0% of the test compound in the diet for fourteen days. Abnormalities observed at the high-dose level included: decreased body weight gain, red blood cell count, hemoglobin concentration and hematocrit; changes in red blood cell morphology; and increased serum aspartate aminotransferase, urea nitrogen, and glucose. Gross and histopathologic abnormalities included darkening of the spleen and splenic congestion. A slight decrease in seruit glucose and splenic congestion were observed at the low-dose level. The test material has been used and sold as a pure chemical.