Record Display for the EPA National Library Catalog

RECORD NUMBER: 83 OF 326

OLS Field Name OLS Field Data
Main Title Initial Submission: Acute Toxicity Studies with Diethylene Glycol Diacrylate with Cover Letter dated 09/11/1992.
CORP Author Industrial Bio-Test Labs., Inc., Northbrook, IL.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-11051
Stock Number OTS0571086
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Diethylene glycol diacrylate ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Rabbits ; Dermal ; Primary eye irritation ; Primary dermal irritation ; Primary dermal sensitization ; Guinea pigs ; CAS No 4074-88-8
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NTIS  OTS0571086 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 05/27/2010
Collation 38p
Abstract
The test material was extremely irritating in the dermal toxicity study. Well defined erythema, severe edema, subdermal hemorrhages, and second and third degree burns were observed at 24 hours. By Day 14, necrosis, eschar, fissuring and wrinkling were observed. The dermal LD50 was between 267 and 400 mg/kg. In the oral toxicity study, antemortem signs included ataxia, salivation, muscular weakness, and convulsions. Hypoactivity was observed at lethal and nonlethal doses. The oral LD50 was 966 mg/kg. Severe, irreversible irritation was observed in the eye and skin irritation studies. Chemical burns and hemorrhages were seen one hour after instillation of the test material in rabbits' eyes. Eye irritation increased in severity throughout the 14 day observation period. In the dermal study, third degree chemical burns and subdermal hemorrhages were recorded at 24 and 72 hours.