||Initial Submission: Acute Oral and Dermal Toxicity of B-Aminocrotonitrile in Rats, Mice, and Guinea Pigs with Cover Letter dated 09/08/1992.
||Eastman Kodak Co., Rochester, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Toxic substances ;
Acute toxicity ;
Guinea pigs ;
CAS No 1118-61-2
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The report pertains to 3-amino-2-butenenitrile (synonym: beta-aminoctotonitrile) (CAS No. 1118-61-2) and is being submitted because of lethality with central nervous system signs observed in an acute oral toxicity test in rats and mice. The oral LDa is 50 mg/kg in rats and 50-100 mg/kg in mice. The material is also a strong skin irritant and its dermal LDa is 0.5-1.0 g/kg in guinea pigs. The report is being identified as a study involving other than human effects (Unit II.B.2.b of CAP Agreement).