Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Ammonium Sulfate Aerosol Exposure on Lung Structure of Normal and Elastase-Impaired Rats and Guinea Pigs.
Author Busch, R. H. ; Buschbom, R. L. ; Cannon, W. C. ; Lauhala, K. E. ; Miller, F. J. ;
CORP Author Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/068;
Stock Number PB84-233246
Additional Subjects Ammonium ; Lung ; Emphysema ; Rats ; Guinea pigs ; Laboratory animals ; Aerosols ; Morphology ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB84-233246 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 22p
Rats and guinea pigs, pretreated with intratracheally administered elastase or saline, were exposed to 1.03 mg/cu. m.(NH4)2SO4. Identically treated controls were sham exposed. Measurements and evaluation of structural changes were conducted using morphometric techniques on SEM photographs and by applying subjective ratings. Pathology studies were conducted by light and electron microscopy. All examination methods confirmed elastase-induced emphysema, which was aggravated by (NH4)2SO4 exposure in the rat. Ammonium sulfate exposure of saline-treated animals produced measurable degrees of enlargement of alveoli, and alveolar ducts and sacs.