||1,2-butylene Oxide: Skin Sensitization Potential in the Guinea Pig with Cover Letter from Bowman Cm, 2020 dow Center to Timm G, Ots dated 01/23/1984.
||Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Butylene Oxide ;
Primary Dermal Sensitization ;
Guinea Pigs ;
Toxic substances ;
Laboratory animals ;
CAS No 106-88-7
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Skin sensitization potential of 1,2- butylene oxide was evaluated in 10 male Hartley albino guinea pigs exposed to 0.1 ml of undiluted test compound 4 times over a 7 day period, followed 2 weeks later by a single challenge exposure. Treatment did not produce signs of sensitization in any of the guinea pigs, whereas 9 of 10 guinea pigs exposed to a positive control solution (0.1 ml of DER 331) exhibited a positive response indicative of sensitization. The authors concluded that the test compound was not a potential human skin sensitizer.