Record Display for the EPA National Library Catalog
RECORD NUMBER: 17 OF 326
|OLS Field Name||OLS Field Data|
|Main Title||Basic Toxicity of Ethylene Glycol Monophenyl Ether (2-Phenoxy Ethanol).|
|CORP Author||National Distillers and Chemical Corp., Cincinnati, OH. Health, Safety, and Environment Dept.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicity ; Rats ; Lethal doses ; Laboratory animals ; Toxic substances ; Eye irritation ; Hazardous materials ; Guinea pigs ; Skin irritation ; Ethylene Glycol monophenyl ether ; 2-phenoxy ethanol|
The acute oral LD50 is 1345 and 1902 mg/kg for male and female rats respectively. Clinical signs of toxicity were slight to severe weakness, unkempt hair coat, ataxia, vasodilation, prostration and death. When applied to the depilated abdomen of guinea pigs under an occlusive wrap for 24 hours the compound produced slight skin irritation. Repeated daily applications to the uncovered, clipped backs of guinea pigs produced only slight erythema. Repeated applications did not exacerbate the response. None of ten guinea pigs tested for skin sensitization exhibited a positive reaction.