| Main Title |
Initial Submission: Teratology Study of Guar Gum in Rabbits with Attachments and Cover Letter dated 08/03/92. |
| CORP Author |
International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920004924 |
| Stock Number |
OTS0542101 |
| Additional Subjects |
Toxicology ;
Health effects ;
Guar Gum ;
Reproduction/fertility effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 9000-30-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0542101 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
150p |
| Abstract |
The developmental effects of guar gum (9000-30-0) were evaluated in groups of 20 rabbits by daily dermal administration of the test substance for 6 hours/day at dose levels of 0, 2, 10 and 50 mg/kg/day on days 6 through 18 of gestation. Surviving animals were sacrificed on day 29 of gestation. Mortalities included 2 deaths at 50 mg/kg/day and 1 death at 10 mg/kg/day. A single animal in the control group was sacrificed in extremis. A dose-related increase in dermal irritation (including erythema, edema, and desquamation) was observed in animals receiving 10 and 50 mg/kg/day. The number of early resorptions was significantly increased and the number of viable fetuses was correspondingly decreased at 50 mg/kg/day (p<0.05). The frequency of fetal malformations and variations in the treated groups was comparable to that of the control group at all dose levels. The NOEL was 2 mg/kg/day. |
