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Main Title Norepinephrine Modulates the Growth-Inhibitory Effect of Transforming Growth Factor-Beta in Primary Rat Hepatocyte Cultures.
Author Houck, K. A. ; Cruise, J. L. ; Michalopoulos, G. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA-R-814344; EPA/600/J-88/467;
Stock Number PB90-147729
Additional Subjects Norepinephrine ; Liver ; Rats ; Deoxyribonucleic acids ; Inhibitors ; Reprints ; Transforming growth factors ; Epidermal growth factor-urogastrone receptors ; Dose-response relationships ; Prazosin ; Alpha adrenergic receptors ; Cultured cells
Library Call Number Additional Info Location Last
NTIS  PB90-147729 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
TGF-beta is a potent inhibitor of EGF-induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five-fold increase, from 2.8 pM to 14.4 pM, in the ID(sub 50) for TGF-beta. The effect was dose-dependent and was significant at concentrations of 10(sup -6)M NE and greater. The modulation by NE was medicated by the alpha(1)-adrenergic receptor as shown by the ability of the alpha(1) antagonist prazosin to block the activity. This effect might be important during liver regeneration in allowing escape of hepatocytes from negative growth control exerted by TGF-beta (Copyright (c) 1988 Alan R. Liss, Inc.)