Record Display for the EPA National Library Catalog


Main Title Evidence for Direct Effect of Magnetic Fields on Neurite Outgrowth.
Author Blackman, C. F. ; Benane, S. G. ; House, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher Jun 93
Year Published 1993
Report Number EPA/600/J-93/413;
Stock Number PB93-236669
Additional Subjects Neurites ; Magnetic fields ; In vitro analysis ; In vivo analysis ; Electric fields ; Nerve growth factors ; Growth ; PC12 cells ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236669 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Electric fields can cause changes in cell responses both in vitro and in vivo. Alternating magnetic fields have been proposed to act through the electric fields induced in the conducting medium surrounding the cells. The authors have used a simple exposure system to test the relative contribution of magnetic fields compared to induced electric fields in a standard PC-12 cell culture assay, in which cells respond to nerve growth factor by producing neurites. This response to stimulation by nerve growth factor is inhibited by sinusoidal, 50-Hz magnetic fields at field strengths below 10 microT (100 mG). A standard procedure to distinguish magnetic- versus electric-field effects demonstrates that the induced electric field is not involved. Additional work is necessary to identify the critical reaction site(s), and to establish the molecular mechanisms responsible for these results.