Record Display for the EPA National Library Catalog


Main Title Effects of NGF and Fetal Cell Transplants on Spatial Learning after Intradentate Administration of Colchicine.
Author Barone, S. ; Tandon, P. ; McGinty, J. F. ; Tilson, H. A. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;East Carolina Univ. School of Medicine, Greenville, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/063;
Stock Number PB92-150770
Additional Subjects Colchicine ; Nerve growth factors ; Fetal tissue transplantation ; Spatial behavior ; Cerebellar nuclei ; Hippocampus ; Immunohistochemistry ; Acetylcholinesterase ; Enkephalins ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-150770 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The study was performed to assess the effects of NGF infusion alone or in combination with fetal hippocampal transplants on recovery of function after damage to hippocampal dentate granule cells. Two groups of male Fischer-344 rats received bilateral infusions of colchicine (COLCH; 2.5 microgram/site) or artificial cerebrospinal fluid (ACSF; 0.5 microliter) through chronic indwelling cannulae into the dentate gyrus. At the time of COLCH injection, a unilateral intracerebroventricular (ICV) cannula was implanted. Morphological examination performed after behavioral testing confirmed the presence of viable transplants and COLCH-induced granule cell loss. These data demonstrate a time-dependent facilitative effect of exogenously applied NGF on functional deficiencies produced by experimentally induced neurodegeneration in the dentate gyrus of the hippocampus.