Record Display for the EPA National Library Catalog


Main Title Health assessment document for talc.
Author Hajjar, N. P. ; Fountos, B. N. ; Kruger-McDermott, C. ; Turck, P. ; Cerny, M. E.
Other Authors
Author Title of a Work
Kotchmar, Dennis J.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency,
Year Published 1992
Report Number EPA 600/8-91/217; EPA-68-03-4140; ECAO-R-0367; PB92239524
Stock Number PB92-239524
OCLC Number 26208125
Subjects Talc--Physiological effect. ; Talc--Toxicology.
Additional Subjects Talc ; Toxicity ; Health hazards ; Carcinogens ; Pulmonary neoplasms ; Fibrosis ; Granuloma ; Risk assessment ; Mutagenicity tests ; Cell survival ; Reproduction(Biology)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA 600/8-91/217 Region 1 Library/Boston,MA 05/25/2016
EJBD ARCHIVE EPA 600-8-91-217 Headquarters Library/Washington,DC 07/31/2012
EJED  EPA-600/8-91/217 OCSPP Chemical Library/Washington,DC 07/24/1992
EKBD  EPA-600/8-91-217 Research Triangle Park Library/RTP, NC 08/21/1992
EKCD  EPA-600/8-91/217 CEMM/GEMMD Library/Gulf Breeze,FL 09/04/2018
ERAD  EPA 600/8-91-217 2 copies Region 9 Library/San Francisco,CA 03/25/2016
ESAD  EPA 600-8-91-217 Region 10 Library/Seattle,WA 08/03/2005
NTIS  PB92-239524 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) ; 28 cm
Talc is made up of pulverized, foliated, hydrous magnesium silicates from minerals with low crystalline silica content. Approximately 1.25 million short tons of talc were produced in the United States in 1989. The largest end uses of talc are in ceramics and paint; 5% is used in cosmetics. Concern over talc exposure is associated with the possible presence of asbestos as a contaminant. Estimates of environmental release of talc are not available. No information was available on the acute toxicity of talc. Subchronic inhalation exposure (3 to 12 mo) in rats resulted in pulmonary fibrosis that increased in severity as the exposure period increased. Chronic exposure by the intratracheal route in hamsters resulted in no observed fibrosis or granulomas. Limited data suggest that talc is not carcinogenic following inhalation exposure or intratracheal instillation in rats and hamsters. Similarly, no evidence of carcinogenicity was noted following intrapleural, intraperitoneal, or oral administration in rats. Several cross-sectional occupational studies of talc miners and millers showed no increase in mortality from lung cancer. For talc without asbestos contamination, the International Agency for Research on Cancer (IARC) has concluded that the available epidemiological and animal toxicity data are inadequate to demonstrate or refute the potential for carcinogenicity.
"EPA 600/8-91/217"--Cover. "March 1992"--Cover. "Office of Research and Development"--Cover. Includes bibliographical references (pages 4-1-4-8). "This document was prepared by Dynamac Corporation under contract no. 68-03-4140, for the Environmental Criteria and Assessment Office, Research Triangle Park, NC; Dennis J. Kotchmar, M.D. project officer"--Page ix.