Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Neuroendocrinology of Female Reproduction: Review, Models, and Potential Approaches for Risk Assessment.
Author Hess, D. L. ;
CORP Author Oregon Regional Primate Research Center, Beaverton. Div. of Reproductive Biology and Behavior.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/293;
Stock Number PB89-202287
Additional Subjects Reproduction(Biology) ; Females ; Hypothalamus ; Pituitary gland ; Toxicology ; Gonadotropins ; Pulse generators ; Reprints ; Neuroendocrinology ; Animal models ; Risk assessment
Library Call Number Additional Info Location Last
NTIS  PB89-202287 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 12/18/1989
Collation 9p
The central role of the mammalian hypothalamic-pituitary axis in regulating female reproductive cycles is reviewed. A variety of animal models and techniques that offer increased sensitivity, speed, and flexibility over traditional reproductive toxicologic approaches for short-term testing or screening are discussed, including the pivotal analysis of gonadotrophin releasing hormone (GnRH) pulse generator activity in vivo and in vitro. Other neuroendocrine techniques that require further development, but provide potential approaches to demonstrate specific sites or mechanisms of action for toxic effects on the hypothalamic-pituitary axis are suggested.