Record Display for the EPA National Library Catalog


Main Title Methyl mercury and the metabolic responses of brain tissue /
Author Bull, Richard J.
CORP Author Health Effects Research Lab., Cincinnati, Ohio. Water Quality Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Available through the National Technical Information Service,
Year Published 1976
Report Number EPA-600/1-76-013
Stock Number PB-252 006
OCLC Number 02484094
Subjects Mercury in the body ; Mercury--Physiological effect ; Brain ; brains
Additional Subjects Mercury organic compounds ; Toxicity ; Mercury poisoning ; Nucleotides ; Recommendations ; Exposure ; Rats ; Responses ; Growth ; Metabolism ; Water pollution ; Laboratory animals ; Experimental data ; Neurology ; Brain damage ; Potable water ; Physiological effects ; Central nervous system ; Ingestion(Biology) ; Glycolysis ; Mercury/chloro-methyl ; Environmental health ; Water pollution effects(Animals)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-76-013 c.1 Headquarters Library/Washington,DC 02/27/2014
EKBD  EPA-600/1-76-013 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD ARCHIVE EPA-600-1-76-013 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-76-013 AWBERC Library/Cincinnati,OH 11/15/2016
NTIS  PB-252 006 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 24 pages : graphs ; 28 cm
Weanling, Sprague-Dawley rats have been exposed to methyl mercuric chloride (concentrations from 0.01 to 10.0 mg/liter) in their drinking water. At 10 mg/liter the animals exhibited neurological symptoms typical of methyl mercury. Also, in this group a considerable decrease in growth occurred which was associated with a decreased consumption of food. Responses of the respiratory intermediates to stimulation were found to be altered in cerebral cortex slices taken from exposed animals. Effects on tissue pyridine nucleotides predominated. An enhancement of the rate of pyridine nucleotide reduction by electrical stimulation was observed at 0.1 mg/liter. This rate progressively decreased at higher dose levels. Reoxidation of reduced pyridine nucleotide was also inhibited at 0.1 mg/liter at both 90 and 180 days of exposure. Potassium stimulated aerobic glycolysis was found to be enhanced in its initial stages at 0.10 mg/liter of methyl mercuric chloride in the drinking water but progressively declined at 1.0 and 10 mg/liter.
Includes bibliographical references (pages 21-23).