Record Display for the EPA National Library Catalog


Main Title Glutamate Neruotoxicity in the Developing Rat Cochlea: Physiological and Morphological Approaches.
Author Janssen, R. ; Schweitzer, L. ; Jensen., K. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Louisville Univ., KY. School of Medicine.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/054;
Stock Number PB91-233403
Additional Subjects Toxicity ; Nervous system ; Cochlea ; Glutamates ; Ganglia ; Afferent neurons ; Synapses ; Neuroregulators ; Rats ; Body weight ; Hair cells ; Physiology ; Morphology ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-233403 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4g/kg/day ip, postnatal days 2 through 9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparations of the organ of Corti revealed no loss of hair cells, there was a dramatic and selective reduction of neurons in the basal, high frequency-related portion of the spiral ganglion. The sensitivity of developing spiral ganglion cells to the neurotoxicity of glutamate is consistent with the hypothesis that glutamate or a structurally related substance is a neurotransmitter at afferent synapses of cochlear hair cells.