||Effects of Low Dosage of Stable Strontium on Serum Enzymes in Chronic Alcoholics.
Stara, J. F. ;
Perras, J. ;
Pivon, R. J. ;
Koch, P. ;
Nolan, J. T. ;
||Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office. ;McGill Univ., Montreal (Quebec). ;La Maison Jean Lapointe, Montreal (Quebec).
Strontium compounds ;
Glucosephosphate dehydrogenase ;
Atomic absorption spectrophotometry ;
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The study shows the systemic effects of low dosage of stable Sr(2+) in relation to chronic ethanol abuse. In the current study, 6 chronic alcoholic patients were administered Sr carbonate (600-700 mg of Sr(2+) per day) for periods of 4-6 weeks, alternating with treatment-free (placebo) intervals. Serum GDH was determined using Koch's modification; GGTP was determined using standard methodology (Gilford Stasar III). Serum ethanol levels were determined using Alcohol Dipstick Methodology of Kapur and Israel. Serum Sr(2+) and Ca(2+) levels were determined by Atomic Absorption Spectrophotometry. In patients receiving Sr(2+), serum GDH levels were decreased 61-68% (range 44.9-88.6%) when compared to the control periods during the acute alcoholic episodes. The effects of Sr(2+) on serum GGTP levels varied in extent of decrease. The preliminary studies indicate that low dosage of Sr(2+) exerts a protective effect on mitochondrial function during acute alcoholic episodes.