Record Display for the EPA National Library Catalog


Main Title Effect of In vivo Ozone Exposure to Dorset Sheep, an Animal Model with Low Levels of Erythrocyte Glucose-6-Phosphate Dehydrogenase Activity (Journal Version).
Author Moore, G. S. ; Calabrese, E. J. ; Schulz, E. ;
CORP Author Massachusetts Univ., Amherst. Div. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1984
Year Published 1984
Report Number EPA-R-805797; EPA/600/J-84/414;
Stock Number PB89-118756
Additional Subjects Sheep ; Ozone ; Toxicity ; Erythrocytes ; Exposure ; Glutathione ; Concentration(Composition) ; Reprints ; Air pollution effects(Animals) ; Glucosephosphate dehydrogenase deficiency
Library Call Number Additional Info Location Last
NTIS  PB89-118756 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Female Dorset sheep were exposed in vivo to ambient ozone levels of 0.12 ppm, 0.25 ppm, 0.50 ppm, 0.70 ppm for 2.75 hours and the effects of this exposure upon erythrocytes were studied. Ozone exposure induced biochemical evidence of oxidant stress as indicated by decreases in reduced glutathione (GSH) levels (at 0.5 and 0.7 ppm ozone) and acetylcholinesterase (at 0.7 ppm), increases in methemoglobin (from 0.12 ppm upward) and decreases in red blood cell counts (0.12 ppm upward). However, only the decrease in GSH levels at the 0.5 ppm ozone exposure was statistically significant (p=0.05). (Copyright (c) 1984 by Chem-Orbital.)