Record Display for the EPA National Library Catalog


Main Title Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury.
Author O'Callaghan, J. P. ; Brinton, R. E. ; McEwen, B. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Rockefeller Univ., New York.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/212;
Stock Number PB91-243030
Additional Subjects Glucocorticoids ; Glial fibrillary acidic protein ; Adrenalectomy ; Stains and staining ; Rats ; Hippocampus ; Cerebral cortex ; Steroids ; Microtubule-associated proteins ; Deoxyribonucleic acids ; Radioimmunoassay ; Trimethyltin ; mRNA ; Northern blotting ; Immunohistochemistry ; Brain injuries ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-243030 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Short (5 days)-to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats. In contrast to CORT, adrenalectomy (ADX) caused elevations (50-125%) in hippocampus and cortex GFAP within 12 days of surgery that persisted for at least 4 months. CORT replacement of ADX rats decreased GFAP amount in hippocampus and cortex. The effects of long-term CORT and ADX on GFAP in hippocampus and cortex were also seen in striatum, midbrain, and cerebellum, findings suggestive of brain-wide adrenal steroid regulation of the astrocyte protein. The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. (Copyright (c) 1991 International Society for Neurochemistry.)