Record Display for the EPA National Library Catalog

RECORD NUMBER: 39 OF 252

Main Title Effect of Hexamethyldisiloxane on the Incidence of Chromosome Breaks and Aberrations in Rat Bone Marrow Cells.
CORP Author Industrial Health Foundation, Inc., Pittsburgh, PA.; Bioassay Systems Corp., Woburn, MA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001601
Stock Number OTS0572636
Additional Subjects Toxicology ; Health effects ; Hexamethldisiloxane ; Toxicity ; Genotoxicity ; Chromosomal effects ; Mammals ; Rats ; Parenteral ; Intraperitoneal ; CAS No 107-46-0 ; Hexamethyldisiloxane (CAS No 107-46-0) ; Toxic substances ; Laboratory animals
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0572636 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 43p
Abstract
Hexamethyldisiloxane was tested for its ability to cause chromosomal damage in bone marrow cells in rats. Sprague-Dawley rats were injected intraperitoneally with 1030, 515 and 255 mg/kg of hexamethyldisiloxane. Doses higher than 1030 were not tested since some lethality was observed at 1825 mg/kg. Animals were sacrificed at 6, 24, or 48 hours after injection; cells were removed, processed and examined for chromosomal breaks and/or aberrations. There was no evidence in this study that hexamethyldisiloxane caused chromosomal damage.