Preface -- Contributors -- Introduction -- Microbial genomes / Voon Loong Chan -- Evolution and origin of virulence isolates / Voon Loong Chan, Philip M. Sherman, and Billy Bourke -- Genomic approach to understanding of infectious disease mechanisms / Voon Loong Chan, Philip M. Sherman, and Billy Bourke -- Knockout and disease models in toll-like receptor-mediated immunity / Huey-Lan Huang and Wen-Chen Yeh -- Campylobacter from glycome to pathogenesis / John Kelly [and others] -- Genomics of helicobacter species / Zhongming Ge and David B. Schauer -- The organization of leptospira at a genomic level / Dieter M. Bulach [and others] -- Listeria monocytogenes / Keith Ireton -- Mycobacterial genomes / David C. Alexander and Jun Liu -- Mycoplasma / Yuko Sasaki -- Genome comparisons of diverse staphylococcus aureus strains / Martin J. McGavin -- Type III secretion, systems in yersinia pestis, and yersinia pseudotuberculosis / James B. Bliska, Michelle B. Ryndak, and Jens P. Grabenstein -- Genomics and the evolution of pathogenic vibrio cholerae / William S. Jermyn [and others] -- Future directions of infectious disease research / Philip M. Sherman, Billy Bourke, and Voon Loong Chan -- Index. Presents major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases. This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria (host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria) host interactions, and diseases mechanisms.