| Main Title |
Synaptonemal Complex Damage as a Measure of Chemical Mutagen Effects on Mammalian Germ Cells. |
| Author |
Allen, J. W. ;
DeWeese, G. K. ;
Gibson, J. B. ;
Poorman, P. A. ;
Moses, M. J. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Duke Univ. Medical Center, Durham, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/028; |
| Stock Number |
PB87-198461 |
| Additional Subjects |
Genetics ;
Mutations ;
Germ cells ;
Chromosomes ;
Toxicology ;
Mitomycins ;
Cyclophosphamide ;
Reproductive system ;
Reprints ;
Synaptonemal complex ;
Enviromental pollutants ;
Health hazards ;
Meiosis ;
Mutagenicity tests ;
Genetic toxicity tests
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-198461 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
As heritable chromosome anomalies are implicated in a variety of human disabilities, their induction in germ cells by environmental chemicals is viewed as a threat to health. Synaptonemal complex (SC) analysis is a novel approach for the detection of germ-line chromosomal damage. This sensitive cytological procedure reveals induced structural damage and pairing abnormalities in SCs of meiotic prophase chromosomes, together with other germ-line toxic effects, in the testes of rodents treated with mitomycin C and cyclophosphamide. Our results demonstrate the effectiveness of SC analysis as a rapid and practical in vivo germ-line mutagen assay that lacks many of the shortcomings of existing tests. (Copyright (c) 1987 Elsevier Science publishers B.V. Biomedical Division.) |
