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Main Title Studies on the Potent Bacterial Mutagen, 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5'H')-Furanone: Aqueous Stability, XAD Recovery and Analytical Determination in Drinking Water and in Chlorinated Humic Acid Solutions.
CORP Author Health Effects Research Lab., Cincinnati, OH. Toxicology and Microbiology Div. ;Cincinnati Univ., OH. Dept. of Chemistry.
Year Published 1987
Report Number EPA/600/J-87/305;
Stock Number PB88-186796
Additional Subjects Mutagens ; Furans ; Potable water ; Water pollution ; Humic acids ; Contaminants ; Water supply ; Chlorination ; Salmonella typhimurium ; Gas chromatography ; Mass spectroscopy ; Toxicology ; Polystyrene ; Reprints ; Furanone/chloro-(dichloro-methyl)-hydroxy
Library Call Number Additional Info Location Last
NTIS  PB88-186796 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was detected by gas chromatography/mass spectrometry in drinking water samples from three locations in the United States, and also in a chlorinated humic acid solution. MX appears to account for a significant proportion of the mutagenicity of these samples, as measured in the Ames test using strain TA100 without metabolic activation. Studies on recovery of MX from spiked water samples by XAD-2/8 resin adsorption/acetone elution indicated that sample acidification prior to resin adsorption was essential to the effective recovery of MX. The stability of MX in aqueous solution was pH- and temperature-dependent. Overall, these results suggest that MX is formed during water chlorination as a result of reaction of chlorine with humic substances, and that a substantial fraction of the MX formed is likely to persist throughout the distribution system.