| Main Title |
Utility of the Murine Erythroleukemic Cell (MELC) in Assessing Mechanisms of Action of DNA-Active Developmental Toxicants: Application to 5-Fluorouracil. |
| Author |
Elstein, K. H. ;
Zucker, R. M. ;
Shuey, D. L. ;
Lau, C. ;
Chernoff, N. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
| Publisher |
1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/386; |
| Stock Number |
PB93-236651 |
| Additional Subjects |
Erythroleukemia ;
Fluorouracil ;
Toxicology ;
Deoxyribonucleic acids ;
Teratogenic compounds ;
Mice ;
S phase ;
Antineoplastic agents ;
Thymidylate synthetase ;
Flow cytometry ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-236651 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Murine erythroleukemic cells (MELC) exposed to 2'-deoxy-5-azacytidine (D-AZA) or to the active cyclophosphamide (CP) metabolites phosphoramide mustard (PAM) and 4-hydroxycyclophosphamide (OHCP) exhibit cell-cycle perturbations similar to those seen in limb bud nuclei of gestational day (GD) 10 CD-1 mouse embryos exposed in utero to D-AZA or CP, respectively. The similarities in response suggest MELC may be a useful model for determining mechanisms of action of DNA-active developmental toxicants. (Copyright (c) 1993 Wiley-Liss, Inc.) |
