Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title DNA Adducts and Induction of Sister Chromatid Exchanges in the Rat Following Benzo(b)-Fluoranthene Administration.
Author Ross, J. A. ; Nelson, G. B. ; Holden, K. L. ; Kligerman, A. D. ; Erexson, G. L. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Kentucky Univ., Lexington.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4456, EPA-R-816185; EPA/600/J-92/438;
Stock Number PB93-141372
Additional Subjects Carcinogenesis ; Toxicology ; Aromatic polycyclic hydrocarbons ; Sister chromatid exchange ; DNA damage ; Rats ; Lymphocytes ; Lung ; Liver ; Reprints ; Benzo(b)fluoranthene ; DNA adducts
Library Call Number Additional Info Location Last
NTIS  PB93-141372 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/12/1993
Collation 6p
Benzo(b)fluoranthene (B(b)F) was administered (100 mg/kg by i.p. injection) to male Sprague-Dawley rats. Lungs, livers, and peripheral blood lymphocytes (PBLs) were harvested 1, 3, 5, 7 14, 28, and 56 days after treatment. Several DNA adducts were observed in each tissue, with maximal levels occurring at about 7 days after treatment. Lung DNA exhibited consistently higher adduct levels than liver or PBL DNA. No significant differences were observed between tissues in the types of adducts produced. Sister chromatid exchanges (SCEs) from whole blood cultures were significantly increased relative to concurrent controls between 1 and 14 days after B(b)F administration, with maximum levels at 14 days.