Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 22

OLS Field Name OLS Field Data
Main Title Studies on the Flavor Aversions Induced by Trialkyltin Compounds.
Author MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-82-301;
Stock Number PB83-189555
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Reprints ; Heavy metals ; Trimethyltin ; Triethylin ; Flavor aversions
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-189555 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Abstract
These experiments were undertaken to determine the suitability of a flavor-aversion-conditioning paradigm for detecting the effects of trimethyltin and triethyltin. Both organotins produced flavor aversions whose magnitude depended jointly on the dosage administered and the number of flavor-organotin pairings. Estimated ED 50s (for triethyltin, 1.8 mg/kg; for trimethyltin, 3.1 mg/kg) were smaller than the dosages reported to affect other classes of behavior, but nevertheless represented a substantial percentage (25-45%) of the respective published LD-50 values. Flavor-aversion conditioning may represent a valuable tool for studying the effects of organic and inorganic heavy metals.