Record Display for the EPA National Library Catalog


Main Title MTBE: Repeated (13-Week) Vapor Inhalation Study in Rats with Neurotoxicity Evaluation and MTBE: Single Exposure Vapor Inhalation Neurotoxicity Study in Rats with Attachments and Letter.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 30 Oct 1989
Year Published 1989
Report Number FYI-OTS-1189-0689;
Stock Number OTS-0000689-3
Additional Subjects Rats ; Neurotoxicity ; Exposure ; Body weight ; Food consumption ; Nervous system ; Motor activity ; Vapor inhalation ; Methyl tertiary butyl ether ; Fischer 344 rats ; Hematologic analysis ; Serum chemistry
Library Call Number Additional Info Location Last
NTIS  OTS-0000689-3 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 820p
Four groups, each consisting of 25 male and 25 female Fischer 344 rats, were exposed 6 hours per day, 5 days per week, for 13 weeks to vapor of methyl tertiary butyl ether (MTBE) at target concentrations of 8000, 400, 800, or 0 (control) ppm. The 8000 ppm concentration was chosen as the high exposure level due to the explosive nature of MTBE. The Environmental Protection Agency in the Section 4 Consent Order agreed to limit the high exposure level to 502 of the lower explosion limit for MTBE (i.e., 8000 ppm). Monitors for toxicity were as follows: daily clinical observations; function observational batted on study weeks 1, 2, 4, 8, and 13. Motor activity on study weeks 4, 8, and 13 body weights; food consumption; hematological analyses; serum chemistry including selected adrenal hormonal analyses: organ weights; and ophthalmic, gross pathologic, and microscopic evaluations. Detailed microscopic evaluations were performed on the nervous system of selected rats (6/sex/group) following perfusion fixation of tissues.