The U.S. Environmental Protection Agency's (EPA's) national program managers (NPMs) develop annual guidance documents to define program priorities, strategies, and performance measures in accordance with the Agency's strategic plan, annual plan and budget, and the Administrator's priorities. We conducted this review to determine how the NPM process relates to the internal control framework under the Federal Managers Financial Integrity Act (FMFIA), and whether the Agency should improve connections between the two processes. We also determined whether NPMs and regional personnel coordinate program management and whether this coordination addresses program risks and vulnerabilities.