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RECORD NUMBER: 302 OF 370

Main Title Support: Letter from Dow Chemical Co. to USEPA regarding 1,3-Dimethyl-2-Imidazolidone with Attachments dated 10/18/1996.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1996
Report Number 8EHQ-1096-13621
Stock Number OTS0558495-1
Additional Subjects Toxicology ; Health effects ; Toxic substances ; 1 ; 3-dimethyl-2-imidazolidinone ; Reproduction ; Fertility effects ; Teratogenicity ; Mammals ; Rats ; Dermal ; CAS No 80-73-9
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Status
NTIS  OTS0558495-1 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract
Preliminary, unaudited results from a dermal teratology study (in which the material was administered for 6 hours/day on gestation days 6 to 15 at 0, 10, 100, and 400 mg/kg/day) indicate a statistically significant decrease in gravid uterine weight and fetal body weight at the 400 mg/kg/day dose level. These parameters were not affected at the 100 or 10 mg/kg/day dose groups. Maternal body weights were significantly decreased at 400 mg/kg/day during gestation days 16-21. Body weight gains of the female rats given 400 mg/kg/day were also statistically decreased on days 6-9, 9-12, 12-16, 0-21 and 6-16. At 100 mg/kg/day, body weight gains were statistically lower than the controls during the treatment period (.days 6-16) and days 19-21 of gestation. No effects on maternal body weights or body weight gains were observed at 10 mg/kg/day.