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RECORD NUMBER: 91 OF 256

Main Title Initial Submission: Letter from Hoechst Celanese Corp Submitting Information on an Oral Study of the Embryotoxic Effect with a Formulation of Glufosinate Nh4 in Wistar Rats.
CORP Author Hoechst Celanese Corp., Summit, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920006596
Stock Number OTS0545195
Additional Subjects Toxicology ; Health effects ; Glufosinate Nh4 ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 77182-82-2
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NTIS  OTS0545195 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Abstract
Glufosinate ammonium (77182-82-2) was evaluated for developmental toxicity. Twenty pregnant Wistar rats per group were administered the test material by oral gavage at 0, 10, 50, or 250 mg/kg/day on days 7- 16 of gestation. Dose-dependent maternal toxicity was observed at all treatment levels including motorial unrest, hyperactivity (50-150 mg/kg/day), drowsiness, vaginal hemorrhages, weight loss, and at 250 mg/kg/day only, intrauterine death and one mortality. Ureter and kidney dilation were observed in fetuses of all treatment groups. A slight retardation of skeletal ossification was observed at 250 mg/kg/day. This study was briefly summarized. No further information was reported.