Record Display for the EPA National Library Catalog
RECORD NUMBER: 152 OF 256| Main Title | Methyl Methacrylate Monomer Teratogenicity in the Rabbit with Attachments and Cover Sheet Dated 07/17/1989 (Sanitized). | |||||||||||
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| CORP Author | Imperial Chemical Industries Ltd., London (England).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 2000 | |||||||||||
| Report Number | 86-890001392S | |||||||||||
| Stock Number | OTS0521015 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Methyl Methacrylate (80-62-6) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Parenteral ; Intraperitoneal ; Toxic substances ; Laboratory animals ; CAS No 80-62-6 | |||||||||||
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| Collation | 10p | |||||||||||
| Abstract | Developmental toxicity was evaluated in groups of 12 female Dutch rabbits injected intraperitoneally with methyl methacrylate at dose levels of 0, 0.004, 0.04, or 0.4 ml/kg bw/day, on gestation days 6-18, followed by fetal examination on gestation day 29. The maternal mortality rate was 25% in all treated groups, probably from complications related to the injection. At the high-dose level, the compound was embryotoxic (increased early resorptions) and fetotoxic (reduced fetal weight and skeletal ossification), but was not teratogenic. |