Record Display for the EPA National Library Catalog
RECORD NUMBER: 127 OF 256
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Teratology Study of 3-Chloro-N-(5-Chloro- 2,6-dinitro-4-Trifluoro- Methyl-Phenyl) 5-Trifluoro-Methyl-Pyridinamine in Rats with Cover Letter dated 08/19/1992.|
|CORP Author||IIT Research Inst., Chicago, IL. Life Sciences Research Div.; CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; 3-Chloro-N-(5-Chloro- 2 ; 6-Dinitro-4-Trifluoro- Methyl-Phenyl) ; Reproduction ; Fertility effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; CAS No 79622-59-6|
The influence of B-1216 upon the progress and outcome of pregnancy was assessed in sexually mature female rats of the CD strain. For this purpose 8-1216 was administered orally, by gastric intubation in corn oil vehicle, at dosages of 10, 50 or 250 mg/kg/day, to groups of 20 pregnant rats from Day 6 to Day 15 inclusive of gestation. Twenty pregnant control animals received the vehicle only, throughout the same period of gestation and at the same volume dosage (10 m1/kg). All females were killed on Day 20 of gestation for examination of their uterine contents.