||Cytoplasmic Microtubular Dynamics and Chromatin Organization during Mammalian Oogenesis and Oocyte Maturation.
Albertini, D. F. ;
||Tufts Univ., Boston, MA. Dept. of Anatomy and Cellular Biology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;National Institutes of Health, Bethesda, MD.
||NIH-HD-20068; EPA/600/J-93/174 ; OHEA-R-477
Follicular phase ;
Germ cells ;
Female genetic risk
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
A chronological series of coordinated alterations in oocyte chromosome and microtubule disposition occur during oogenesis and oocyte maturation in the mammal. Timely transitions in meiotic spindle and cytoplasmic microtubules, due to modifications in both the assembly competence of the tubulin pool and nucleation capacity of centrosomes, underscore key nuclear events during the progressive stages of meiosis I and II. The regulation of these transitional states during meiosis is discussed with respect to hormonal influences imparted to the oocyte within the follicular microenvironment, and the possible ways in which environmental perturbations may result in defective chromosomal partitioning during meiosis. (Copyright (c) 1992 Elsevier Science Publishers B.V.)