||Gene Expression in Pre-Implantation Mammalian Embryos.
Schultz, G. A. ;
Heyner, S. ;
||Calgary Univ. Health Sciences Centre (Alberta). Dept. of Medical Biochemistry. ;Pennsylvania Univ. Medical Center, Philadelphia. Dept. of Obstetrics and Gynecology.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.;National Institutes of Health, Bethesda, MD.
||NIH-HD23511; EPA/600/J-93/171 ; OHEA-R-474
Preimplantation phase ;
Gene expression ;
Genetic transcription ;
Cell membrane ;
Biological transport ;
Species diversity ;
Growth substances ;
Female genetic risk ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The pre-implantation mammalian embryo is initially under the control of maternal informational macromolecules that are accumulated during oogenesis. Subsequently, the genetic program of development becomes dependent upon new transcription derived from activation of the embryonic genome. Several embryonic transcripts including those that encode growth factors, cell junction components and plasma membrane ion transporters are required for normal progression of the embryo to the blastocyst stage. The pattern of genes expressed and the overall program of development is subject to the influences of genomic imprinting as well as external influences encountered by the embryo within the maternal reproductive tract. (Copyright (c) 1992 Elsevier Science Publishers B.V.)