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Main Title NTP Technical Report on Toxicity Studies of Cupric Sulfate (CAS No. 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3F1 Mice.
Author Hebert, C. D. ;
CORP Author National Toxicology Program, Research Triangle Park, NC.
Publisher Jul 93
Year Published 1993
Report Number NIH/PUB-93-3352 ;NIH/TOX-29;
Stock Number PB94-120870
Additional Subjects Toxicity ; Oral administration ; Rats ; Mice ; Survival ; Body weight ; Hematology ; Pathology ; Feeding behavior ; Organ weight ; Drinking behavior ; Copper sulfate ; CAS 7758-99-8
Library Call Number Additional Info Location Last
NTIS  PB94-120870 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 122p
Cupric sulfate is an inorganic salt which is widely used in industry, agriculture, and veterinary medicine. Its applications include use as an algicide in potable waters and as a feed additive and therapeutic agent in swine, sheep, and cattle. Because copper salts are found in human water supplies, toxicity studies of cupric sulfate pentahydrate were conducted in male and female F344/N rats and B6C3F1 mice by the drinking water (2-week studies only) and dosed feed routes (2-week and 13-week studies). Animals were evaluated for hematology, clinical chemistry, urinalysis, reproductive toxicity, tissue metal accumulation, and histopathology. In summary, administration of cupric sulfate to rats in feed or drinking water resulted in significant gastric changes and hepatic and renal damage.