Main Title |
Effects of Pentachlorophenol-Contaminated Food Organisms on Toxicity and Bioaccumulation in the Frog 'Xenopus laevis'. |
Author |
Schuytema, G. S. ;
Nebeker, A. V. ;
Peterson, J. A. ;
Griffis, W. L. ;
|
CORP Author |
Corvallis Environmental Research Lab., OR. ;ManTech Environmental Technology, Inc., Corvallis, OR. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/148; |
Stock Number |
PB93-191450 |
Additional Subjects |
Xenopus laevis ;
Pentachlorophenol ;
Toxicity ;
Food chains ;
Water pollution effects(Animals) ;
Pesticides ;
Dose-response relationships ;
Feeding behavior ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-191450 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Sub-adult African clawed frogs (Xenopus laevis) were fed pentachlorophenol (PCP)-injected mealworms containing 64.8 to 2,604 mg of PCP per kilogram of worm for 27 days. The objective was to evaluate the effects of PCP-contaminated food organisms on toxicity and bioaccumulation in sub-adult Xenopus laevis and use the data to predict a waterborne PCP concentration that may be a threshold for adverse effects in amphibians. There was no mortality and no significant bioaccumulation of PCP in the frogs. After three weeks, frogs fed 2,604 micrograms/g of PCP ceased eating. The no observed adverse effects level (NOAEL) based on significantly reduced food consumption (PCP-injected mealworms) was 638 micrograms/g. This corresponded to a NOAEL based on PCP intake of about 8 micrograms PCP/g frog/day. A toxicity threshold model estimated that about 800 micrograms/L of waterborne PCP may be a threshold for adverse effects in Xenopus or similar amphibians. Further study is needed to verify threshold estimates. |