Record Display for the EPA National Library Catalog


Main Title Effects of Pentachlorophenol-Contaminated Food Organisms on Toxicity and Bioaccumulation in the Frog 'Xenopus laevis'.
Author Schuytema, G. S. ; Nebeker, A. V. ; Peterson, J. A. ; Griffis, W. L. ;
CORP Author Corvallis Environmental Research Lab., OR. ;ManTech Environmental Technology, Inc., Corvallis, OR.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/148;
Stock Number PB93-191450
Additional Subjects Xenopus laevis ; Pentachlorophenol ; Toxicity ; Food chains ; Water pollution effects(Animals) ; Pesticides ; Dose-response relationships ; Feeding behavior ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-191450 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Sub-adult African clawed frogs (Xenopus laevis) were fed pentachlorophenol (PCP)-injected mealworms containing 64.8 to 2,604 mg of PCP per kilogram of worm for 27 days. The objective was to evaluate the effects of PCP-contaminated food organisms on toxicity and bioaccumulation in sub-adult Xenopus laevis and use the data to predict a waterborne PCP concentration that may be a threshold for adverse effects in amphibians. There was no mortality and no significant bioaccumulation of PCP in the frogs. After three weeks, frogs fed 2,604 micrograms/g of PCP ceased eating. The no observed adverse effects level (NOAEL) based on significantly reduced food consumption (PCP-injected mealworms) was 638 micrograms/g. This corresponded to a NOAEL based on PCP intake of about 8 micrograms PCP/g frog/day. A toxicity threshold model estimated that about 800 micrograms/L of waterborne PCP may be a threshold for adverse effects in Xenopus or similar amphibians. Further study is needed to verify threshold estimates.