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Main Title Autonomic and Behavioral Thermoregulation in the Golden Hamster during Subchronic Administration of Clorgyline.
Author Gordon, C. J. ; Duncan, W. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;National Inst. of Mental Health, Rockville, MD. Clinical Psychobiology Branch.
Publisher cMay 94
Year Published 1994
Report Number EPA/600/J-94/530;
Stock Number PB95-148920
Additional Subjects Body temperature regulation ; Clorgyline ; Animal behavior ; Autonomic nervous system ; Pharmacology ; Monoamine oxidase inhibitors ; Mesocricetus ; Drug administration schedule ; Motor activity ; Feeding behavior ; Body weight ; Regression analysis ; Metabolism ; Reprints ; Golden hamsters
Library Call Number Additional Info Location Last
NTIS  PB95-148920 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Chronic administration of clorgyline, a type-A monoamine oxidase inhibitor, leads to a decrease in peritoneal (i.e., core) temperature of golden hamsters. To better understand the mechanisms of clorgyline's thermoregulatory effects, autonomic and behavioral thermoregulatory effectors were measured in Syrian hamsters following chronic infusion of clorgyline via a minipump (2 mg/kg/day). Metabolic rate, evaporative water loss, motor activity, and core temperature were measured after 60 min of exposure to ambient temperatures (T(sub a)) of 5, 20, 30, and 35 C. Behavioral thermoregulatory responses were assessed by measuring selected T(sub a) and motor activity of the same animals in a temperature gradient over the course of 23 h. Metabolic rate and motor activity were significantly elevated in clorgyline-treated hamsters exposed to a T(sub a) of 5 C. There were no effects of clorgyline on evaporative water loss. In the temperature gradient the mean selected T(sub a) of clorgyline-treated hamsters was nearly equal to that of the saline-treated hamsters, 30.7 and 31.2 C, respectively. On the other hand, the mode of selected T(sub a) in the clorgyline group was 2.8 C higher than that of the saline group. Motor activity in the gradient was significantly elevated and food consumption was depressed by clorgyline treatment.