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Main Title Examination of the Reproductive Effects of Tricresyl Phosphate Administered to Long-Evans Rats.
Author Carlton, B. D. ; Basaran, A. H. ; Mezza, L. E. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Battelle Columbus Labs., OH.
Year Published 1987
Report Number EPA/600/J-87/350;
Stock Number PB88-214747
Additional Subjects Phosphorus organic compounds ; Reproduction(Biology) ; Toxicity ; Pathology ; Organic phosphates ; Laboratory animals ; Rats ; Germ cells ; Fertility ; Fecundity ; Growth ; Ovary ; Testis ; Reprints ; Toxic substances ; Tritolyl phosphate ; Tricresyl phosphate ; Phosphoric acid/tris(methylphenyl) ester
Library Call Number Additional Info Location Last
NTIS  PB88-214747 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The reproductive effects of tricresyl phosphate (TCP) were examined. Male Long-Evans rats received 0, 100, or 200 mg/kg and females received 0, 200, or 400 mg/kg TCP in corn oil by gavage. Males were dosed for 56 days and females for 14 days prior to breeding and throughout the 10-day breeding period. Following breeding, the males were necropsied and evaluated for sperm parameters and reproductive tract histopathology. Females were dosed throughout gestation and lactation. Pups and adult females were necropsied on postnatal day 21. Sperm concentration, motility, and progressive movement were decreased for 200 mg/kg dose groups males. A dose-dependent increase in abnormal sperm morphology was observed for males in both TCP dose groups. The percent of sperm-positive females per group was unchanged, but the number of females delivering live young was severely decreased by TCP exposure. Litter size and pup viability was decreased in the 400 mg/kg dose group. Pup body weight and developmental landmarks were unaffected by TCP exposure. Histopathologic changes were observed in the testes and epididymides of male rats and in the ovaries of female rats exposed to TCP. (Copyright (c) 1987 by Elsevier Scientific Publishers Ireland Ltd.)