A feasibility study was performed on a general purpose materials non-destructive evaluation (NDE) expert system. The research included a survey of several NDE applications in U.S. industry, from which power plant piping was selected as an example for demonstration of the expert system concept. The elements of conventional NDE application were identified, from inspection scheduling to data analysis and ultimate disposition of inspection findings. Computer software to implement the major elements were identified and combined into an overall expert system framework consisting of three modules which emulate the decisions of skilled NDE, metallurgy, and design and fracture mechanics personnel. The feasibility of the expert system was demonstrated through application to four specific power plant pipe welds, which exercise various aspects of the evaluation process.