Sodium 2,4,6-tribromophenate has been tested for acute toxicity to rabbits and rats. New Zealand white rabbits (3/sex) received 0.1 ml of test material in the conjunctival sac of one eye that was left unwashed for 24 hours, then monitored for signs of irritation for 21 days. The substance was extremely irritating (scores ranged from 63 to 89). A primary skin irritation study with similar groups of rabbits treated with 0.5 ml of test material applied under a covered patch to clipped, abraded skin yielded a primary irritation score of 3.0, indicative of mild skin irritation. The acute dermal LD50 for the rabbit (tested with 8/sex/group) was 14,142 (8,663 to 23,087) mg/kg for combined sexes. Hypoactivity and decreased limb tone were noted in the 20,000 mg/kg group, but not in the 10,000 mg/kg or less groups. An acute oral toxicity test was conducted with Sprague-Dawley rats (25/group) administered doses of 1000 to 6308 mg/kg by gavage in distilled water. An LD50 value of 3162 (2776 to 3602) mg/kg for combined sexes was identified. Pharmacotoxic signs observed during the 14-day observation period included hypoactivity, decreased limb tone, ataxia, and in the 2 highest dose groups, tremors, decreased pain response, and loss of grasping, pinna, and placing reflexes.