Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Proceedings of the ISEA (International Society of Exposure Analysis) Bioavailability Symposium Held in Durham, North Carolina, in October, 2007. Use of 'In Vitro' Bioaccessibility/Relative Bioavailability Estimates for Metals in Regulatory Settings: What Is Needed.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. National Exposure Research Lab.
Year Published 2007
Report Number EPA/600/R-08/102; NERL-RTP-HEASD-08-021
Stock Number PB2008-113476
Additional Subjects Bioavailability ; Bioaccessibility ; Metals ; Exposure analysis ; Risk assessments ; Analytical chemistry ; International ; Europe ; Canada ; Foreign countries ; In vitro ; Animal models ; Research tools ; Exposure assessments ; Toxicology ; Mineralogical analyses ; Physiologically based models ; Contaminated sites ; Regulatory settings
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2008-113476 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 110p
Oral ingestion of soil and dust is a key pathway for human exposures to metal and metalloid contaminants. It is widely recognized that the site-specific bioavailability of metals in soil and dust may be reduced relative to the metal bioavailability in media such as water and food, and adjustments for oral relative bioavailability are becoming more accepted. Both animal models and 'in vitro' bioaccessibility models have been used to estimate relative bioavailability of metals in soil and dust. Although animal models are often considered the 'gold standard', they may be costly or otherwise prohibitive at certain sites and may not be sensitive enough to test environmentally relevant samples for all contaminants. Routine application of 'in vitro' metal bioaccessibility models in regulatory settings is being held up by different perceptions of what is required of these models in terms of validation. This symposium provided the opportunity for international experts to exchange their views on methods for assessing relative bioavailability/bioaccessibility for application in risk assessments at contaminated sites. The symposium speakers presented recent developments in animal models, new 'in vitro' models, the role of mineralogical analyses in assessing relative bioavailability, and the application of physiologically based models as research tools. In addition, two panel discussions addressed specific research questions and discussed future research needs in this area. Recognizing the multi-disciplinary nature of exposure assessment, this symposium included representation from many disciplines including risk assessment, toxicology, environmental geochemistry, geology, soil, and analytical chemistry from the U.S., Europe, and Canada.