Record Display for the EPA National Library Catalog


Main Title Transgenic animal mutagenicity assays /
Other Authors
Author Title of a Work
Wahnschaffe, U.
Publisher World Health Organization,
Year Published 2006
Report Number EHC 233
OCLC Number 77516640
ISBN 9789241572330; 9241572337; 9789241572337
Subjects Mutagenicity testing ; Transgenic animals ; Genetic toxicology ; Health risk assessment ; Mutagenicity Tests ; Animals, Genetically Modified--genetics ; Mutagens--toxicity ; Organismes génétiquement modifiš ; Mutations provoques ; Toxicité ; Mutageniteit ; Transgene organismen ; Mutagãenese (testes) ; Camundongos (genética) ; Mediðcäao de risco ; Exposiðcäao ambiental ; Transgene Tiere ; Versuchstiere ; Mutagenitätstest ; Camundongos (genâetica) ; Mutagenitèatstest ; Mutag enese (testes)--larpcal ; Camundongos (genetica)--larpcal ; Medi c ao de risco--larpcal ; Exposi c ao ambiental--larpcal
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJEM  RA565.A1E58 no. 233 OCSPP Chemical Library/Washington,DC 01/19/2009
ELBM  RA565.A1E63 2006 no.233 AWBERC Library/Cincinnati,OH 08/19/2013
Collation xxv, 298 pages : illustrations.
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." "International Programme on Chemical Safety"--Cover. Includes bibliographical references (pages 179-214).
Contents Notes
Part 1. Overview of genotoxicity testing and transgenic animal mutagenicity systems -- Overview of genotoxicity testing -- Constructions/production of transgenic animals using as examples the lacI and lacZ mutation models -- The transgenic mutagenicity assay-methodology using as examples lacI and lacZ mutation models -- Further transgenic mutagenicity assays -- Parameters and criteria for valid experimental design -- Part 2. Comparison of the lacI model and the lacZ model with conventional test systems -- Introduction to part 2 -- Comparison of the Muta (superscript TM) mouse and Big Blueª assays -- Transgenic assays-comparison with other assays -- Transgenic assays and carcinogenicity testing -- Part 3. Applications of transgenic animal mutagenicity studies -- Mutation frequencies and sequencing data and applications of this information in mechanistic studies -- Part 4. Evaluation, conclusions and recommendations -- Evaluation of the transgenic animal mutagenicity assays based on this review of the current literature -- Conclusions -- Recommendations. This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.