Record Display for the EPA National Library Catalog
RECORD NUMBER: 5 OF 11| Main Title | Initial Submission: Range Finding Toxicity and 7-Day Dietary Inclusion Studies of Ethylenediamine with Cover Letter dated 09/08/1992. | |||||||||||
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| CORP Author | Carnegie-Mellon Univ., Pittsburgh, PA.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 8EHQ-0992-11022 | |||||||||||
| Stock Number | OTS0571059 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Toxic substances ; Ethylenediamine ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Rabbits ; Dermal ; Primary dermal irritation ; Primary eye irritation ; Subchronic toxicity ; Diet ; CAS No 107-15-3 | |||||||||||
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| Collation | 15p | |||||||||||
| Abstract | Inclusion for seven days of ethylenediamine in the diet of rats resulted in statistically significant dosage-related reductions of body weight in both sexes, and decreases in liver weight per as and in liver weight/body weight ratios. Kidney weight/body weight ratios were significantly increased. Tubular nephrosis was found in both sexes at the two highest dosage levels. No significant effects in either sex were observed at 0.20 gm/kg/day. The ratio of single peroral LD50/MiE vas 2.24, indicating a moderate degree of chronicity. The median predicted minimum effect dosage level for 90-day rat feeding is 0.167 ge/kg; that for two years is 0.093 p/kg (Weil et al., Tox. Appl. Pharmacol 14, 426-431, 1969). |