Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 2| Main Title | Initial Submission: Ethylene Glycol Monoethyl Ether Acetate: Probe Inhalation Teratogenicity Study in Rabbits with Cover Letter dated 07/24/92. | |||||||||||
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| CORP Author | Imperial Chemical Industries Ltd., Billingham (England).; Dow Corning Corp., Hemlock, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 88-920005030 | |||||||||||
| Stock Number | OTS0544004 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Ethylene Glycol Monoethyl Ether Acetate ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 111-15-9 | |||||||||||
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| Collation | 26p | |||||||||||
| Abstract | Ethylene glycol monoethyl ether acetate (111-15-9) was evaluated for developmental effects in groups of 8 female Dutch rabbits administered the test substance by inhalation for 6 hours/day on days 6 through 18 of gestation at concentrations of 0, 100, 250, or 450 ppm. Animals were sacrificed on day 21 of gestation. Reduced bodyweight gain and food consumption was seen in the 100, 250, and 450 ppm groups during the first few days of exposure. Fetal weights were reduced at 100, 250, and 450 ppm. The number of live fetuses per litter was reduced at 450 ppm (not statistically significant). |