Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 4
|Main Title||Combined Use of Biochemical Indicators to Assess Sublethal Pollution Effects on the Gulf Killifish ('Fundulus grandis').|
|Author||Schoor, W. P. ; Williams, D. E. ; Lech, J. J. ;|
|CORP Author||Environmental Research Lab., Gulf Breeze, FL. ;Medical Coll. of Wisconsin, Inc., Milwaukee. Dept. of Pharmacology and Toxicology.|
|Additional Subjects||Fishes ; Water pollution ; Toxicology ; Chico Bayou ; Oxidoreductases ; Liver ; Reprints ; Fundulus grandis ; Gulf killifish ; Water pollution effects(Animals) ; Water pollution detection ; Enzyme induction ; Cytochrome P-450 ; Anyl hydrocarbon hydroxylases ; Ethoxyresorufin O-deethylase|
Sublethal biochemical markers were used to identify liver enzyme induction in fish from a bayou in Pensacola, Florida. Gulf killifish, Fundulus grandis, from a nonpolluted site were used in the study which included laboratory-induced fish and their various controls as well as the fish captured in the bayou. The biochemical markers tested were liver to body weight ratios, total content of cytochrome P-450, mixed function oxygenase and ethoxyresorufin-O-deethylase activities, and the specific induction of the ML4b isozyme of the cytochrome P-450 system. The findings suggest that enzyme induction occurred at a sublethal level, indicating the presence of liver enzyme inducing substances in the bayou.