Record Display for the EPA National Library Catalog

RECORD NUMBER: 6 OF 6

OLS Field Name OLS Field Data
Main Title Testing of Selected Workplace Chemicals for Teratogenic Potential with Attachments, Cover Sheets and Letter dated 02/25/81.
CORP Author National Inst. for Occupational Safety and Health, Cincinnati, OH. Div. of Biomedical and Behavioral Science. ;Litton Bionetics, Inc., Rockville, MD.;Shell Oil Co., Houston, TX.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 2 Mar 1981
Year Published 1981
Report Number 8HEQ-0381-0386;
Stock Number OTS-0204918
Additional Subjects Toxicity ; Industrial medicine ; Chemical compounds ; Exposure ; Hazardous materials ; Laboratory animals ; Rats ; Rabbits ; Risk factors ; Inhalation ; Laboratory tests ; Occupational safety and health ; Concentration(Composition) ; Teratogenic potential ; 2-Ethoxyethanol ; Embryotoxicity
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NTIS  OTS-0204918 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/09/2008
Collation 63p
Abstract
The reproductive toxicity and teratogenic potential of 19 industrial chemicals have been investigated during the past 3 years. Preliminary studies in rats, utilizing intraperitoneal treatments on days 1-15 of gestation, have been conducted on 10 chemicals: allyl chloride, bisphenol A, copper naphthenate, ethylene dibromide, hexachlorobutadiene, 2-mercaptobenzothiazole, methyl styrene, naphthalene, 2-nitropropane, and 1,2,3-trichloropropane. Studies in rats and rabbits, utilizing inhalation exposure on days 1-19 and 1-24, respectively, of gestation, have been conducted on 9 chemicals: butylene oxide, carbon disulfide, 2-ethoxyethanol, ethyl benzene, methyl bromide, nitrous oxide, styrene oxide, tetrachloroethylene, and trichloroethylene. In the preliminary studies, evidence of teratogenic potential was seen with allyl chloride and bisphenol A, and fetal toxicity was seen in the absence of maternal toxicity with methyl styrene and 2-nitropropane. In the inhalation studies, 2-ethoxyethanol was strongly embryotoxic at the higher exposure levels employed, and was teratogenic at the lower concentration.