The reproductive toxicity and teratogenic potential of 19 industrial chemicals have been investigated during the past 3 years. Preliminary studies in rats, utilizing intraperitoneal treatments on days 1-15 of gestation, have been conducted on 10 chemicals: allyl chloride, bisphenol A, copper naphthenate, ethylene dibromide, hexachlorobutadiene, 2-mercaptobenzothiazole, methyl styrene, naphthalene, 2-nitropropane, and 1,2,3-trichloropropane. Studies in rats and rabbits, utilizing inhalation exposure on days 1-19 and 1-24, respectively, of gestation, have been conducted on 9 chemicals: butylene oxide, carbon disulfide, 2-ethoxyethanol, ethyl benzene, methyl bromide, nitrous oxide, styrene oxide, tetrachloroethylene, and trichloroethylene. In the preliminary studies, evidence of teratogenic potential was seen with allyl chloride and bisphenol A, and fetal toxicity was seen in the absence of maternal toxicity with methyl styrene and 2-nitropropane. In the inhalation studies, 2-ethoxyethanol was strongly embryotoxic at the higher exposure levels employed, and was teratogenic at the lower concentration.